Having initially struggled with the injury, the former champion won three races from summer onwards as his recovery progressed. Six-time MotoGP title winner Marc Márquez made a comeback in the third race of the year after his arm and shoulder injury that ended his 2020 season at the first event. In total, eight different riders have won Grands Prix during the season. In the overall standings, Bagnaia is in second and reigning champion Joan Mir is in third place with two races remaining. The season also saw Francesco Bagnaia and Jorge Martín win their first premier class races.
Quartararo became the first ever Frenchman to win the premier class title, which was also the first title for a non-Spanish rider since Australian Casey Stoner in 2011. Fabio Quartararo won his first world title, with five race wins ahead of securing the title in the third last race of the season. The 2021 FIM MotoGP World Championship is the premier class of the 73rd F.I.M.